Tag Archives: vorinostat

The foetal haemoglobin story just got more complicated

Many of us think that foetal haemoglobin (Hb F) is the key to a “cure” for sickle cell disease. The genes that make Hb F are switched off shortly after we are born and then remain inactive throughout the rest … Continue reading

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What are “HDAC” inhibitors?

HDAC inhibitors are a group of drugs, which have a wide range of actions, including the ability to modify the activity of genes. HDAC stands for “Histone De-ACetylase” and the HDAC inhibitors are drugs which inhibit this enzyme. They may … Continue reading

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Update on clinical trials in sickle cell disease

MST-188 Otherwise known as Purified Poloxamer 188, is a designated orphan drug by the US Food and Drug Administration (FDA) for trial in sickle cell disease. It is a synthetic co-polymer of polyoxyethylene (POE) and polyoxypropylene (POP) and is thought … Continue reading

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