Tag Archives: hydroxycarbamide

Hydroxycarbamide and “silent cerebral infarcts”

The first reports dating from 1995 showed that taking hydroxycarbamide regularly reduced the frequency of painful crises and of the acute chest syndrome and also reduced the need for blood transfusion. This breakthrough has since been followed by numerous reports … Continue reading

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A long life with sickle cell disease

Sickle cell disease is often described as a “life limiting disorder”. Not so long ago children and teenagers were sometimes told that they would be “lucky to see their 21st birthday”. In many parts of the world it remains the … Continue reading

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Knock down of BCL11A

There is great excitement in the sickle cell world at the moment about, what may turn out to be, a turning point in the the long road to find a practicable cure for sickle cell. A recent paper from the … Continue reading

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More on asthma and sickle cell

A team of French sickle cell doctors, from the Robert-Debre Hospital in the Sorbonne, Paris, have been studying a group of 375 babies identified at birth with sickle cell disease. Following them up carefully, recording what happens to them and … Continue reading

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Pomalidomide – more action on the foetal haemoglobin front

As many of you will know hydroxycarbamide is the only drug licensed for the treatment of sickle cell disease. It’s potential benefits in sickle cell were only discovered by accident, many years ago, when patients were being treated with the … Continue reading

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The foetal haemoglobin story just got more complicated

Many of us think that foetal haemoglobin (Hb F) is the key to a “cure” for sickle cell disease. The genes that make Hb F are switched off shortly after we are born and then remain inactive throughout the rest … Continue reading

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Research interest and funding in sickle cell

The autumn has brought a rush of new publications on sickle cell disease and the 9th Sickle Cell & Thalassaemia Conference, organised by Dr Baba Inusa from Guy’s & St Thomas’ Hospital (7th to 9th October 2015), clarified many of … Continue reading

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