Tag Archives: gamma-beta switch

Knock down of BCL11A

There is great excitement in the sickle cell world at the moment about, what may turn out to be, a turning point in the the long road to find a practicable cure for sickle cell. A recent paper from the … Continue reading

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Pomalidomide – more action on the foetal haemoglobin front

As many of you will know hydroxycarbamide is the only drug licensed for the treatment of sickle cell disease. It’s potential benefits in sickle cell were only discovered by accident, many years ago, when patients were being treated with the … Continue reading

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The foetal haemoglobin story just got more complicated

Many of us think that foetal haemoglobin (Hb F) is the key to a “cure” for sickle cell disease. The genes that make Hb F are switched off shortly after we are born and then remain inactive throughout the rest … Continue reading

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Homing in on BCL11A

I mentioned BCL11A in a previous blog (More on Haemoglobin F – 16/04/14). It is a protein molecule which is critically important for switching off the production of haemoglobin F (Hb F) after birth and for maintaining low levels of … Continue reading

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Haemoglobin F

So, why is haemoglobin F so important when we are thinking about possible treatments for sickle cell disease? Well, let’s start at the beginning with haemoglobin itself and then move on to discuss haemoglobin F. Haemoglobin is what gives blood … Continue reading

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