Category Archives: sickle cell disease

Crizanlizumab; a new, effective drug for sickle cell?

The results of a major, new trial in sickle cell disease (SUSTAIN) have just been published in the New England Journal of Medicine and presented at the American Society of Haematology meeting in San Diego. The trial involved the novel … Continue reading

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Hydroxycarbamide and “silent cerebral infarcts”

The first reports dating from 1995 showed that taking hydroxycarbamide regularly reduced the frequency of painful crises and of the acute chest syndrome and also reduced the need for blood transfusion. This breakthrough has since been followed by numerous reports … Continue reading

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A long life with sickle cell disease

Sickle cell disease is often described as a “life limiting disorder”. Not so long ago children and teenagers were sometimes told that they would be “lucky to see their 21st birthday”. In many parts of the world it remains the … Continue reading

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Knock down of BCL11A

There is great excitement in the sickle cell world at the moment about, what may turn out to be, a turning point in the the long road to find a practicable cure for sickle cell. A recent paper from the … Continue reading

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Poloxamer 188 – helpful during a painful crisis or not?

Research involving Poloxamer 188 (also know as RheothRx or MST 188) continues to appear in the journals. The latest is some interesting work from a team working in Hungary and France published in the British Journal of Haematology (1). Poloxamer … Continue reading

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More on asthma and sickle cell

A team of French sickle cell doctors, from the Robert-Debre Hospital in the Sorbonne, Paris, have been studying a group of 375 babies identified at birth with sickle cell disease. Following them up carefully, recording what happens to them and … Continue reading

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Asthma and sickle cell disease

In celebration of World Sickle Cell Day on June 19th The Lancet has published a series of specially commissioned articles on controversial topics in sickle cell. The first, written by Michael DeBaun, from Vanderbilt University, Nashville and Robert Strunk, from … Continue reading

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Re-wiring the brain and chronic pain

Pain is a deceptively simple experience. If you hit your thumb with a hammer you feel instant pain, which peaks rapidly and then gradually resolves over a few days as the damaged tissues repair themselves. In theory a painful crisis … Continue reading

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Pomalidomide – more action on the foetal haemoglobin front

As many of you will know hydroxycarbamide is the only drug licensed for the treatment of sickle cell disease. It’s potential benefits in sickle cell were only discovered by accident, many years ago, when patients were being treated with the … Continue reading

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Automated red cell exchange transfusion – NICE gives the OK

NICE, the National Institute for Clinical Excellence, has just published guidance on the preferred way of undertaking exchange transfusions in sickle cell disease. These recommendations have major implications for all those living with sickle cell in the UK, and will … Continue reading

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