Category Archives: red cell adhesion

Crizanlizumab; a new, effective drug for sickle cell?

The results of a major, new trial in sickle cell disease (SUSTAIN) have just been published in the New England Journal of Medicine and presented at the American Society of Haematology meeting in San Diego. The trial involved the novel … Continue reading

Posted in drug trials, pain, red cell adhesion, sickle cell disease | Tagged , , , , | Leave a comment

Poloxamer 188 – helpful during a painful crisis or not?

Research involving Poloxamer 188 (also know as RheothRx or MST 188) continues to appear in the journals. The latest is some interesting work from a team working in Hungary and France published in the British Journal of Haematology (1). Poloxamer … Continue reading

Posted in drug trials, pain, red cell adhesion, sickle cell disease | Tagged , , , , | Leave a comment

Sticky red cells – learning about the glue

The key clinical feature of sickle cell disease is pain, which is usually experienced as coming from the bones or joints. Typically, the pain begins with little or no warning, quickly builds in intensity to a maximum and then gradually … Continue reading

Posted in red cell adhesion, sickle cell disease | Tagged , , , , , , | 10 Comments