Category Archives: pain

Crizanlizumab; a new, effective drug for sickle cell?

The results of a major, new trial in sickle cell disease (SUSTAIN) have just been published in the New England Journal of Medicine and presented at the American Society of Haematology meeting in San Diego. The trial involved the novel … Continue reading

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Poloxamer 188 – helpful during a painful crisis or not?

Research involving Poloxamer 188 (also know as RheothRx or MST 188) continues to appear in the journals. The latest is some interesting work from a team working in Hungary and France published in the British Journal of Haematology (1). Poloxamer … Continue reading

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Asthma and sickle cell disease

In celebration of World Sickle Cell Day on June 19th The Lancet has published a series of specially commissioned articles on controversial topics in sickle cell. The first, written by Michael DeBaun, from Vanderbilt University, Nashville and Robert Strunk, from … Continue reading

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Re-wiring the brain and chronic pain

Pain is a deceptively simple experience. If you hit your thumb with a hammer you feel instant pain, which peaks rapidly and then gradually resolves over a few days as the damaged tissues repair themselves. In theory a painful crisis … Continue reading

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Automated red cell exchange transfusion – NICE gives the OK

NICE, the National Institute for Clinical Excellence, has just published guidance on the preferred way of undertaking exchange transfusions in sickle cell disease. These recommendations have major implications for all those living with sickle cell in the UK, and will … Continue reading

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Cannabis, sickle cell and new concepts in chronic pain

Professor Kalpna Gupta, who works at the University of Minnesota in the US, gave an interesting talk at the 9th Sickle Cell & Thalassaemia Conference in London last week. The talk covered her investigations into the use of cannabis as … Continue reading

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Opiate pain killers and addiction in sickle cell disease

I have been prompted to write this blog, about one of the most difficult and contentious issues in sickle cell, having been to a conference at the Royal Society of Medicine on “Chronic Pain and Opiate Addiction”. Drug addiction is … Continue reading

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