Category Archives: drug trials

Crizanlizumab; a new, effective drug for sickle cell?

The results of a major, new trial in sickle cell disease (SUSTAIN) have just been published in the New England Journal of Medicine and presented at the American Society of Haematology meeting in San Diego. The trial involved the novel … Continue reading

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Hydroxycarbamide and “silent cerebral infarcts”

The first reports dating from 1995 showed that taking hydroxycarbamide regularly reduced the frequency of painful crises and of the acute chest syndrome and also reduced the need for blood transfusion. This breakthrough has since been followed by numerous reports … Continue reading

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Poloxamer 188 – helpful during a painful crisis or not?

Research involving Poloxamer 188 (also know as RheothRx or MST 188) continues to appear in the journals. The latest is some interesting work from a team working in Hungary and France published in the British Journal of Haematology (1). Poloxamer … Continue reading

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Pomalidomide – more action on the foetal haemoglobin front

As many of you will know hydroxycarbamide is the only drug licensed for the treatment of sickle cell disease. It’s potential benefits in sickle cell were only discovered by accident, many years ago, when patients were being treated with the … Continue reading

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Red cell dehydration

We generally understand the term “dehydration” to mean that our body is short of water. It is a potentially dangerous condition, particularly in sickle cell, and normally the amount of water in the body is very carefully controlled and regulated. … Continue reading

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The foetal haemoglobin story just got more complicated

Many of us think that foetal haemoglobin (Hb F) is the key to a “cure” for sickle cell disease. The genes that make Hb F are switched off shortly after we are born and then remain inactive throughout the rest … Continue reading

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Research interest and funding in sickle cell

The autumn has brought a rush of new publications on sickle cell disease and the 9th Sickle Cell & Thalassaemia Conference, organised by Dr Baba Inusa from Guy’s & St Thomas’ Hospital (7th to 9th October 2015), clarified many of … Continue reading

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