I am a consultant haematologist who worked in Hackney, London, UK with patients who have sickle cell disease for many years. Knowledge is power. I hope this blog will empower patients by putting them in touch with contemporary research into sickle cell disease and facilitating informed discussion about the issues raised.
Dr Roger Amos MA, MD, FRCPath.

The header picture is from an original batik by Richard Kimbo, of Nairobi, Kenya, entitled “Market Scene”.

5 Responses to About

  1. Jibril Abukar says:

    Dear Dr Amos
    I am wondering if you could enlighten us in regarding to pregnant ladies with homozygous hereditary persistence of haemoglobin F. As HbF has got high affinity for oxygen how does the foetus extract oxygen from maternal blood?

    Jibril Abukar

    • rogerjamos says:

      Hi Jibril
      This would be a very unusual situation – patients with 100% Hb F are very uncommon and I have never met this situation myself in a pregnant woman. I suppose the thing to remember is that since the baby and the woman would both have 100% Hb F there would be no difference in the affinity of their blood for oxygen. Oxygen would therefore tend to move down the concentration gradient, from high levels in the mother to low levels in the baby. So the baby would still be supplied with oxygen but perhaps not just as efficiently as in the normal situation where oxygen uptake in the baby is further facilitated by the higher affinity of Hb F for oxygen compared to Hb A. Hope that makes sense – best wishes Roger

  2. June says:

    Hello Dr Amos, I recently posted a blog link on a facebook page called Sickle Cell Warriors with about 14,000 members. I think this may be a great space to interact with a wider audience of patients and their carers. I do benefit from it and I think more can benefit from your exceptional knowledge. Also I have posted a few questions in the previous week or two and I would appreciate if you could please support with them Dr Amos :). Thank you for continued care for sickle cell patients.

  3. deemdre says:

    Hello Dr. Amos,

    I was wondering if you knew where I can find more information about the history of sickle cell before the first diagnosis. I love your blog post that discussed sickle cell and slavery in New Orleans. Do you know where I can find more information on Charles Jackson and the history of sickle cell and slavery?


    • rogerjamos says:

      Hi Kadeem – I tried very hard to find out more information about Charles Jackson but information was very limited and is there in the blog. If you have any more success I would be very interested to hear about it. Before the description of the first patient in the western scientific literature by Herrick in 1910 there is very little information although the disease had clearly been known to the peoples of west Africa for many centuries. The link below is a good place to start.


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